Capillary Electrophoresis Methods for Pharmaceutical Analysis

Capillary Electrophoresis Methods for Pharmaceutical Analysis

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Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control. - Provides current status and future developments in CE analysis of pharmaceuticals. - Explains how to develop and validate methods. - Includes major pharmaceutical applications including assays and impurity testing.Figure 12 shows a schematic representation of the mechanisms in MEKC. ... a a#39;a#39; migration window, a#39;a#39; between the migration time of the EOF (70% solubilization) peak (teof) and the migration time of the micellar (7100% solubilization) peak ( tmc).

Title:Capillary Electrophoresis Methods for Pharmaceutical Analysis
Author:Satinder Ahuja, Mohamedilias Jimidar
Publisher:Elsevier - 2011-08-09


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