This Useras Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The Useras Guide was created by researchers affiliated with AHRQas Effective Health Care Program, particularly those who participated in AHRQas DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)Use of radical cystectomy as initial therapy for the treatment of high-grade T1 urothelial carcinoma of the bladder: A SEER database ... The validity of ICD-9- CM diagnosis codes for identifying patients hospitalized for COPD exacerbations.
|Title||:||Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide|
|Author||:||Agency for Health Care Research and Quality (U.S.)|
|Publisher||:||Government Printing Office - 2013-02-21|