Important questions whether mechanistic models would allow allometric scaling among species were addressed in Chapter 2. The PK/PD model of rHuEPO was looked at in terms of three components, including PK, pharmacology, and system-related parameters and their correlation to body size were assessed. Most PK parameters and system parameters for RBC and precursor lifespans generally obeyed principles of allometry, but the pharmacologic parameters appeared to be species specific.C Consult the usera#39;s manual for details concerning the format for * C entered equations and definition of symbols. * C * C 1. DiffEq- System ... PK parameters Real*8 Smax, SC50, Imax, IC50, Tr, Tp, Teb, Trbc, Tfb, Ko, Ro !PD Real*8 MCH, MCV, M1anbsp;...
|Title||:||Disposition and Dynamics of Recombinant Human Erythropoietin|
|Publisher||:||ProQuest - 2007|