Uterine leiomyomata (fibroids) are responsible for substantial morbidity, especially among African Americans. Gene expression studies suggest IGF-I involvement in fibroid pathogenesis; IGFBP-3 may be important based on biological interrelations with IGF-I. IGF-I and IGFBP-3 polymorphisms have not been previously studied with fibroids. We evaluated the IGF-I and IGFBP-3 SNPs and estimated diplotypes from our first study in association with fibroid prevalence in our African American and Caucasian study population. Relatively precise prevalence differences (PD) with IGF-I and IGFBP-3 SNPs were predominantly estimated among African Americans, including IGFBP-3 SNPs of rs9282734 (His158Pro) (PD = -0.130, 95% CI: -0.294, 0.034) and rs2475551 (splice site) (PD = 0.208, 95% CI: 0.095, 0.320) and IGF-I SNP rs35767 (promoter) (PD = 0.208, 95% CI: 0.095, 0.320). Associations with larger fibroids (2+ cm) were consistent or slightly weaker than with any fibroids. Diplotype associations were not consistent with SNP findings. Future research should validate our findings and examine additional genes within the IGF-I pathway.... WA), Acuson 128 XP (Siemens, Issaquah, WA), or Diasonics DRF 400 (GE, Milwaukee, WI) ultrasound systems. Information collected by sonographers included the size and location of the two largest fibroids and the number of tumors withinanbsp;...
|Title||:||Evaluation of Insulin-like Growth Factor Polymorphisms with Prevalence and Size of Uterine Leiomyomata|
|Publisher||:||ProQuest - 2007|