In this monograph the authors have emphasized a number of important concepts in mammalian kidney development. Emphasis has been put on methodology so that the reader can understand how certain results or conclusions were reached and what the optimal methods for reliable results to be obtained are. In addition, as well as descriptions of the morphology there is information on the genetic basis of the structural development. In addition much attention has been paid to how nephron number may be altered by changes in the environment of the developing kidney and to the consequences for the remaining nephron gene expression and kidney function when total nephron number is altered. The consequences for the health of the adult, upon the formation of an adult kidney with altered nephron number and (potentially) gene expression, can be quite serious. The epigenetic mechanisms by which such changes can occur are introduced as a very fertile field for future investigation.... been reliable, but several laboratories have used this technique with great skill and success (see for example Lelievre-Pegorier et al. 1998 ... to select genes for further investigation based on gene ontology, biological pathways, and/or the membrane organization of the protein. ... To answer such questions, researchers have employed isolation techniques such as manual micro-dissection (Stuart et al.
|Title||:||Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life|
|Author||:||Karen Moritz, E. Marelyn Wintour-Coghlan, M. Jane Black, John F. Bertram, Georgina Caruana|
|Publisher||:||Springer Science & Business Media - 2008-05-11|