Taken together, these results emphasize the utility of precise labeling and gene knockout in revealing novel mechanisms for the formation of specific connections in neural networks. Additionally, these results set the stage for the future identification of preprogrammed and activity-dependent mechanisms for patterning connections in the mammalian nervous system.migration could be important for granule cell wiring. For instance, mutant cells that fail to migrate properly may be left behind by sister wild type cells; thus, clonally-related cells would fail to correlate mossy fiber input to granule cell output in theanbsp;...
|Title||:||Genetic Mosaic Analysis of Lineage and Activity in Wiring the Mouse Brain|
|Publisher||:||ProQuest - 2009|