This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in qimmune surveillanceq against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers.A Comprehensive Review of Structure and Function Bjarte Gees Solheim, Erna Moller, Soldano Ferrone ... Furthermore, the role played by class II antigens in the immune network needs to be elucidated. It is not known, for example, how the class II antigen of a specific activated T cell interacts with the same type of molecule ... Bensussan A, Meuer SC, Schlossman SF, Reinherz EL (1984) Delineation of an immunoregulatory amplifier population recognizing autologous Ia molecules.
|Title||:||HLA Class II Antigens|
|Author||:||Bjarte Gees Solheim, Erna Moller, Soldano Ferrone|
|Publisher||:||Springer Science & Business Media - 2012-12-06|