High levels of homocysteine have been identified as a very important risk factor in cardiovascular disease. Homocysteine-related abnormalities are also thought to contribute to birth defects and dementia, and there are many common acquired diseases, drugs and genetic disorders which adversely affect the metabolism of homocysteine. In this 2001 book a multidisciplinary team of experts in the field give a clear analysis of the biochemistry, genetics, epidemiology, clinical settings, causes, impact and treatment of homocysteine disorders. This is an unusually comprehensive account of the broad range of medical, nutritional and methodological implications of homocysteine in health and disease.When control fibroblasts are incubated with labeled cyanocobalamin, virtually all of the label is ultimately found as adenosylcobalamin ... accumulate excess cobalamin, but it remains as unmetabolized, nonprotein-bound cyanocobalamin in lysosomes (149, 177). ... of homocysteine to methionine by methionine synthase (Metabolic Diagram, Reaction 4), the methyl group of 5- methyltetrahydrofolate isanbsp;...
|Title||:||Homocysteine in Health and Disease|
|Author||:||Ralph Carmel, Donald W. Jacobsen|
|Publisher||:||Cambridge University Press - 2001-07-19|