Insecticides Design Using Advanced Technologies

Insecticides Design Using Advanced Technologies

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In the past, insecticide development has been guided mostly by chemo-rational and bio-rational design based on understanding of the physiology and ecology of insects and crops. A limitation in each new class of compounds is the evolution of resistance in populations of key pests, which ultimately leads to control failures. This phenomenon and the desire to produce more selective and biorational compounds serve as the driving force to develop advanced technologies for insecticide design. Among the highlights of this book are the use of nanotechnology to increase potency of available insecticides, the use of genetic engineering techniques for controlling insect pests, the development of novel insecticides that bind to unique biochemical receptors, the exploration of natural products as a source for environmentally acceptable insecticides, and the use of insect genomics and cell lines for determining biological and biochemical modes of action of new insecticides.It was estimated that close to 60% (Merisko-Liversidge 2002) of the new chemical entities currently in the discovery stage, primarily using high throughput screening practice, are poorly water soluble (solubility below 0.1 mg/l). The problem isanbsp;...

Title:Insecticides Design Using Advanced Technologies
Author:Isaac Ishaaya, Ralf Nauen, A. Rami Horowitz
Publisher:Springer Science & Business Media - 2007-02-15


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