Molecular Genetics of Liver Neoplasia

Molecular Genetics of Liver Neoplasia

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Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500, 000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking. Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumora€™s aggressiveness at the time of diagnosis and the lack of effective therapy.White (Hispanic and non-Hispanic) Other (Asian) Black 9 8 8 8.4 7.9 7.2 7.2 6.6 7 6.3 6 6 5 5 5.2 4.6 4 3 2.5 2.5 2.5 2.6 2.9 1.4 3.4 3.7 3.9 ... the other two were from national databases in which risk factors were ascertained from ICD-9 codes in billing or discharge records. ... 2 Risk Factors of Hepatocellular Carcinoma HCC is unique in that it largely occurs within an established background of chronic liveranbsp;...

Title:Molecular Genetics of Liver Neoplasia
Author:Xin Wei Wang, Joe W. Grisham, Snorri S. Thorgeirsson
Publisher:Springer Science & Business Media - 2010-11-08


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