Alzheimer's disease is the most common form of dementia in the elderly; 450, 000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associate proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.Note the prominent distortion of ABAD in the presence of AI², with deformation of the LBDB loop as well as the NAD binding ... (a) A ribbon diagram with labelled secondary structures and the LBDB, LBEB, and LBFB loops. ... (c) Superposition of AI²-bound human ABAD (pink) and rat ABAD in complex with NAD (blue).
|Title||:||Neurobiology of Alzheimer's Disease|
|Author||:||David Dawbarn, Shelley J. Allen|
|Publisher||:||Oxford University Press, USA - 2007|