This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a amust reada for all those involved in vaccine development, both in academia and industrial vaccine development.... 54-eng.php; http://www.health.state.mn.us/divs/idepc/immunize/mnvfc/ bfaxarchive/ bf15dec09.pdf; ... However, most of these mutations reduce virus growth in cultured cells and/or eggs and may thus not allow efficient vaccine production. ... A lab-adapted human influenza A virus (A/WSN/33, H1N1; WSN) with mutations in the nuclear localization signal of M1 replicated comparably to wild-type virus inanbsp;...
|Title||:||Novel Technologies for Vaccine Development|
|Author||:||Igor Lukashevich, Haval Shirwan|
|Publisher||:||Springer - 2014-11-13|