Oocyte Biology in Fertility Preservation

Oocyte Biology in Fertility Preservation

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a€‹Fertility preservation has become one of the most important and fast growing fields of reproductive medicine. Although there are several strategies for fertility preservation in female, most of them are still considered experimental. It is important to perfect the existing technologies, but also developing new strategies should be actively sought. The future development of fertility preservation strategies should be based on the sound scientific knowledge and principles. One of the main objectives of fertility preservation in females is prevention of oocyte depletion. The mechanisms of oocyte loss and survival in the ovary are complex, which include genetic control both in germ cells and in somatic cells, DNA damage and repair mechanism, apoptosis and autophagy, and other poorly understood molecular mechanisms. To develop clinically effective and safe strategies for fertility preservation, it is essential to know and understand the fundamentals of oocyte and ovarian biology at the molecular level. Thus, the purpose of this edition is to review the current progress in research related to molecular and genetic control of oocyte development that can be applied to fertility preservation. The main topics that are discussed in this publication include molecular signaling mechanisms of oocyte activation and loss, genomic integrity of oocytes, and epigenetics.a€‹2010). The process of apoptosis and autophagy following stress and damage to germ cells and somatic cells is an important topic to investigate ... leading to cell death, unless active repair mechanisms kick in to rescue DNA damage caused by radiation, chemotherapy, or cryoinjury in a timely manner. ... The concept and technology of gamete production in vitro from pluripotent stem cells is revolutionary.

Title:Oocyte Biology in Fertility Preservation
Author:S. Samuel Kim
Publisher:Springer Science & Business Media - 2013-10-05


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