PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.List. of. contributors. Jonathan K. Armstrong, Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, California 90033, USA; e-mail:anbsp;...
|Title||:||PEGylated Protein Drugs: Basic Science and Clinical Applications|
|Author||:||Francesco M. Veronese|
|Publisher||:||Springer Science & Business Media - 2009-12-30|