This volume focuses on how to increase the efficiency of drug discovery and development. It is written by experienced discovery scientists from diverse disciplines, including chemistry, drug metabolism, and development sciences. The volume details in silico, in vitro, and in vivo tools for prediction, measurement, and application of compound properties to select and improve potential drug candidates.The best way to solve a permeability or solubility problem is with chemistry. The key to avoiding this ... This common practice is something to be avoided at all costs. The most efficient method to solve aqueous solubility problems is in chemistry.
|Title||:||Pharmaceutical Profiling in Drug Discovery for Lead Selection|
|Author||:||Ronald Borchardt, Edward Kerns, Christopher Lipinski, Dhrien Thakker, Binghe Wang|
|Publisher||:||Springer Science & Business Media - 2005-12-05|