This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.Editor Sanjay K. Srivastava Biomedical Sciences Texas Tech University Health Sciences Center Amarillo, TX, USA ISBN 978-94-007-6316-6 ISBN 978-94-007- 6317-3 (eBook) DOI ... New York London Library of Congress Control Number: 2013936405 Ac Springer Science+Business Media Dordrecht 2013 This work is subject to copyright. ... paper Springer is part of Springer Science+Business Media (www.springer.com) Dedicated to my loving family, my wife Rekha and adoring.
|Title||:||Role of Capsaicin in Oxidative Stress and Cancer|
|Author||:||Sanjay K. Srivastava|
|Publisher||:||Springer Science & Business Media - 2013-04-23|