This comprehensive ebook covers all the aspects of ADME/PK modeling including solubility, absorption, formulation, metabolic stability, drug-drug interaction potential and a special delivery tool of drug candidates. the book provides an integrated view of fundamental ADME issues and challenges in early drug development from the aspect of practicing drug researchers. It also provides valuable help for the medicinal chemist in the process of multiple optimization.It has been clearly demonstrated that solubility is one of the major factors affecting the in vivo systemic exposure of drug candidates. Drug companies usually aim ... a short overview of the practice of solubility measurement. INTRODUCTION Inanbsp;...
|Title||:||Solubility, Delivery and ADME Problems of Drugs and Drug-Candidates|
|Author||:||Karoly Tihanyi, Monika Vastag|
|Publisher||:||Bentham Science Publishers - 2011-01-01|