It is now established that dysregulated cell stress response pathways play a critical role in tumorigenesis, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit cancer patients in the near future. Coauthored by recognized leaders in cancer research from five continents, this novel book provides a comprehensive perspective on cell stress response pathways and therapeutic opportunities. Focusing on the role of genotoxic, proteotoxic, oxidative, metabolic, and inflammatory stress in tumorigenesis, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in cancer and therapeutic development.Among emerging molecular strategies that enable targeted intervention, the concept of a#39;synthetic lethalitya#39; has ... 2010). For example, a synthetic-lethal mechanism of action determines selectivity of PARP-1 inhibitors targeting ... CUX1 function in base excision repair as an ancillary factor for the 8-oxoG-DNA glycosylase OGG1 is consistent with the ... display transformation-associated alterations increasing the intracellular redox-active LIP (Yang and Stockwell 2008; Wondrak 2009).
|Title||:||Stress Response Pathways in Cancer|
|Publisher||:||Springer - 2014-11-07|