Ambifunctional axially chiral 2, 2', 6, 6'-tetrasubstituted biphenyls containing nucleophilic (or basic) functional groups juxtaposed with hydrogen-bond donors were synthesized and their properties studied. Applications for the prepared biaryls as potential organocatalysts for enantioselective carbon-carbon bond forming reactions were examined. Processes investigated included: aldol, Michael, nitroaldol (Henry), and Baylis-Hillman reactions.(61) Schlosser, M. Organometallics in Synthesis: A Manual; 2nd ed.; Wiley: New York, 2004. (62) Bayardon, J.; Sinou, D. ARKIVOC 2008, VII, 26-35. (63) Chelucci , G. Chem. Soc. Rev. 2006, 35, 1230-1243. (64) Castillon, S.; Claver, C.; Diaz, anbsp;...
|Title||:||Synthesis of Novel Ambifunctional Atropisomeric 2,2',6,6'-tetrasubstituted Biphenyls and Investigation of Their Properties and Organocatalytic Activity|
|Publisher||:||ProQuest - 2008|