A trial-based spatial working memory (WM) paradigm, where trial type was unpredictable at encoding, was used to evaluate differential predictions of various models of SWM organization in humans (Study 1) and disruptions in this network in patients with schizophrenia (Study 2). Study 1 revealed that both maintenance (M) and manipulation (MnM) trials were associated with activation of frontal, parietal, occipital and thalamic regions, with significantly greater activation for MnM than for M. In both trial types, occipital cortex and FEF were more active in the early phase while the left frontal pole and VLPFC were more active in the later phase. These results suggest a relatively greater role of DLPFC, FEF, premotor and thalamus in MnM of a maintained representation, and a relatively greater role of VLPFC in comparison operations and response selection.While both animal (Fuster, 1997, 2000; Goldman-Rakic, 1995, 1996; Funahashi and Kubota, 1994; Funahashi, Chefee, aamp; Goldman-Rakic 1993; Funahashi, Bruce, aamp; Goldman-Rakic, 1993) and human (Smith and Jonides, 1996, 1997, 1998;anbsp;...
|Title||:||The Cognitive Neuroscience of Maintenance and Manipulation in Spatial Working Memory and Their Disruption in Schizophrenia|
|Publisher||:||ProQuest - 2008|