The first comprehensive book on the subject, The Genetic Basis of Sleep and Sleep Disorders covers detailed reviews of the general principles of genetics and genetic techniques in the study of sleep and sleep disorders. The book contains sections on the genetics of circadian rhythms, of normal sleep and wake states and of sleep homeostasis. There are also sections discussing the role of genetics in the understanding of insomnias, hypersomnias including narcolepsy, parasomnias and sleep-related movement disorders. The final chapter highlights the use of gene therapy in sleep disorders. Written by genetic experts and sleep specialists from around the world, the book is up to date and geared specifically to the needs of both researchers and clinicians with an interest in sleep medicine. This book will be an invaluable resource for sleep specialists, neurologists, geneticists, psychiatrists and psychologists.neurons in the LDT/PPT during wakefulness [1, 58]. ... a pivotal role in the maintenance of wakefulness, although OXR-1 has additional effects on sleepa wake regulation. ... Transgenic mice with ubiquitous orexin overexpression are resistant to high-fat diet-induced obesity and insulin ... Effective doses of almorexant did not cause any significant negative effects on next-day performance (assessed by fine motor testing and mean reaction time), as is commonly observed with currentanbsp;...
|Title||:||The Genetic Basis of Sleep and Sleep Disorders|
|Author||:||Paul Shaw, Mehdi Tafti, Michael J. Thorpy|
|Publisher||:||Cambridge University Press - 2013-10-24|