The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry

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The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed qThe Bibleq by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. * The only book available dealing with the practical aspects of medicinal chemistry * Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production * Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistryMany pharmaceutical companies thus dropped research programs on natural products in favor of chemical synthesis ... The only exception to this was with fermentation programs, which were continued in some cases as the logistics were well ... the fungi Monascus ruber, Aspergillus terreus and Penicillium citrinum.11 These are followed by the hypertensive agents, ... design of combinatorial strategies, as exemplified by the 2 million plus compound library that was recently assembledanbsp;...

Title:The Practice of Medicinal Chemistry
Author:Camille Georges Wermuth
Publisher:Academic Press - 2003-06-11


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