As the first detailed overview of the subject, Tight Junctions brought together diverse perspectives from leading investigators to provide a multidisciplinary overview of the field. Since its publication in 1992, there has been an explosion of information about tight junctions, particularly in the area of molecular structure, cell and molecular biology, genetics and physiology. The field has advanced so fast and so far that it influences many areas of biology and now has practical implications for pharmacology of drug delivery and understanding a wide range of diseases altering epithelial permeability.... cleft that is closed at both ends by tight, gap and adhering junctions (Diagram a ) (Pelletier and Friend, 1983; Pelletier, 1986; 1988). ... The association of the annular junctional profiles with autophagic vacuoles or with lysosomes is suggestive of two ... Moreover, the internalization of surface cellular junctions and their fusion with lysosomes has been traced with the filipin-labeling technique ( Risingeranbsp;...
|Author||:||Marcelino Cereijido, James M. Anderson|
|Publisher||:||CRC Press - 2001-06-26|