This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce the most significant changes in urine. This book tries to show researchers and graduate students, who are in or entering the field, qall things consideredq rather than qthe current affairq.... modifications . Peptide sequencing by nano-RP-HPLC-ESI-MS/MS was performed as previously described as well as protein identification using either a nanoflow HPLC system (Agilent 1, 200 series) coupled with an ion trap (modelanbsp;...
|Title||:||Urine Proteomics in Kidney Disease Biomarker Discovery|
|Publisher||:||Springer - 2014-10-29|