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Three members of the genus Yersinia are important human pathogens, causing diseases ranging from the deadly Plague (Yersinia pestis) to a relatively mild gastroenteritis (Y. enterocolitica and Y. pseudotuberculosis). Plague, a re-emerging disease, is endemic in many parts of the world. The extraordinary pathogenicity of Y. pestis makes it a potential bioterrorist weapon. On the other hand, the two enteropathogenic Yersinia species represent the third most common bacterial cause of gastroenteritis in Europe and probably elsewhere, although their prevalence is largely underestimated. This, and the emergence of antibiotic resistant Y. pestis in recent years, highlights the urgency to understand the mechanisms of pathogenicity and the need to devise new strategies for the prevention and control of human pathogenic Yersinia. In this book, leading Yersinia researchers review the hot topics in the systems biology and the control of these important bacteria. Topics include: transcriptome analysis of the bacterial response to the host, and of the host response, to a Yersinia infection * proteome analysis of the bacterial and host responses * treatment and antibiotic resistance * vaccines * surveillance * control. The book will be essential reading for everyone working on Yersinia and related organisms. It is recommended reading for researchers interested in biodefense, microbial genomics, and the evolution of microbial virulence.In a rat with bubonic plague, a single inguinal bubo can be quickly dissected and its contents, which contain up to 108 Y. pestis, released ... Comparative transcriptomics of the flea and bubo life-cycle stages of Y. pestis Positive signals were detected for 55% and 66% of the ... The top diagram represents sets of genes for which transcripts were detected in the flea only, in the bubo only, or in both hosts.

Author:Elisabeth Carniel, Bernard Joseph Hinnebusch
Publisher:Horizon Scientific Press - 2012


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